Faculty
Arruda, Ellen
Department Chair of Mechanical Engineering, Professor of Mechanical Engineering, Biomedical Engineering, and Macromolecular Science and Engineering
734-763-5328
Charles Brooks
Cyrus Levinthal Distinguished University Professor of Chemistry and Biophysics; Warner-Lambert/Parke-Davis Professor of Chemistry; Director of Biophysics
7346476682
Understanding the forces that determine the structure, dynamics and reactivity of proteins, peptides, nucleic acids, and complexes containing these molecules, and the processes by which the structures are adopted is essential to extend our knowledge of the molecular nature of structure and function. To address such questions, we develop new methods from statistical mechanics, quantum mechanics and statistical modeling and utilize these methods in molecular simulations to study structure/function/reactivity relationships in systems of biological importance. Ongoing efforts in the Brooks Group are directed toward answering critical questions that provide insights into function and inform experiment on key problems in biomedicine, e.g., drug discovery and refinement, protein-protein interactions, protein/enzyme engineering and re-engineering, protein folding and misfolding, and in biological function that results from or in large scale assembly or reorganization of biological macromolecules and their assemblies. Our group focuses on fundamental methodological developments but also engages extensively in collaborative efforts with our experimental colleagues at the University of Michigan and elsewhere. Current projects include drug discovery and design through the development and application of cutting edge free energy simulation methods and small molecule docking approaches; fundamental investigations of the role that pH plays in modulating and mediating molecular processes in the context of cellular physiology. Protein folding and misfolding, protein-protein association and the interactions of intrinsically disordered proteins with their protein targets are also being pursued through collaborative studies, including one focused on transcriptional activation. The re-design of enzymes to exploit their exquisite control of stereo- and/or region-specific chemistry for pharmaceutically interesting chemical syntheses. The development and application of machine learning methods, and protein ancestral reconstruction approaches are also being utilized in the context of many of the above noted problems. Significant computational resources are necessary to realize these objectives, and this need motivates our efforts aimed at the efficient use of new computer architectures, including large supercomputers and computational grids. We are a key site for the development of the CHARMM software and work extensively on its continued development and the implementation of critical computational kernels on advanced computational hardware, including graphically processing units (GPUs). Our group oversees a local computing facility of approximately 5000 cpu cores and 300 GPUs, which facilitate the development and many of the applications noted above.
Chen, Zhan
Professor of Chemistry and Macromolecular Science and Engineering
734-615-4189
Glotzer, Sharon
Department Chair of Chemical Engineering, Professor of Chemical Engineering, Material Science and Engineering, Macromolecular Science and Engineering, and Physics
734-615-6296
Gong, Xiwen
Assistant Professor of Chemical Engineering, Macromolecular Science & Engineering, Electrical Engineering and Computer Science, Applied Physics, and Materials Science & Engineering
734-615-3127
Goodson III, Theodore
Professor of Chemistry and Macromolecular Science and Engineering
734-647-0274
Guo, L. Jay
Director of Macromolecular Science and Engineering, Professor of Electrical Engineering and Computer Science, Mechanical Engineering, and Applied Physics
734-647-7718
Kamcev, Jovan
Assistant Professor of Chemical Engineering and Macromolecular Science and Engineering
734-647-1195
Kim, Jinsang
Raoul Kopelman Collegiate Professor of Science and Engineering
734-936-4681
Kotov, Nicholas
Professor of Chemical Engineering, Materials Science and Engineering, and Macromolecular Science and Engineering
734-763-8768
Lahann, Joerg
Director of the Biointerfaces Institute, Professor of Chemical Engineering, Biomedical Engineering, Macromolecular Science and Engineering, and Materials Science and Engineering
734-763-7543
Laine, Richard
Professor of Materials Science and Engineering, and Macromolecular Science and Engineering
734-764-6203
Larson, Ronald
Professor of Chemical Engineering and Macromolecular Science and Engineering
734-936-0772
Liu, Albert
Assistant Professor of Chemical Engineering and Macromolecular Science and Engineering
734-763-5192
Love, Brian
Professor of Material Sciences and Engineering, Macromolecular Science and Engineering, and Biomedical Engineering
734-763-2013
Ma, Peter
Professor of Biologic and Materials Sciences, Macromolecular Science and Engineering, Materials Science and Engineering, and Biomedical Engineering
734-764-2209
Matzger, Adam
Professor of Chemistry and Macromolecular Science and Engineering
734-615-6627
McCrory, Charles
Associate Professor of Chemistry and Macromolecular Science and Engineering
734-763-8060
McNeil, Anne
Professor of Chemistry and Macromolecular Science and Engineering
734-615-5204
Mehta, Geeta
Associate Professor of Materials Science & Engineering, Biomedical Engineering and Macromolecular Science and Engineering
734-763-3957
Min, Jouha
Assistant Professor of Chemical Engineering, Macromolecular Science & Engineering, and Biomedical Engineering
Nikolla, Eranda
Professor of Chemical Engineering and Macromolecular Science and Engineering
734-763-5167
Pena-Francesch, Abdon
Assistant Professor of Materials Science and Engineering, Macromolecular Science and Engineering, and Robotics Institute
Shikanov, Ariella
Associate Professor of Biomedical Engineering and Macromolecular Science and Engineering
734-615-3360
Shtein, Max
Professor of Materials Science and Engineering and Macromolecular Science and Engineering
734-764-4312
Sodano, Henry
Professor of Aerospace Engineering, Materials Science and Engineering, and Macromolecular Science and Engineering
734-763-6728
Solomon, Michael
Dean and Vice Provost for Academic Affairs – Graduate Studies, Rackham Graduate School, Professor of Chemical Engineering and Macromolecular Science and Engineering
734-764-3119
Stegemann, Jan
Professor of Biomedical Engineering and Macromolecular Science and Engineering
734-764-8313
Taub, Alan
Professor of Materials Science and Engineering, Mechanical Engineering, and Macromolecular Science and Engineeirng
734-763-1024
Tuteja, Anish
Professor of Materials Science and Engineering and Macromolecular Science and Engineering
734-615-2972
VanEpps, Scott
Associate Professor of Emergency Medicine & Clinical Lecturer, Biomedical Engineering, and Macromolecular Science and Engineering
734-763-2702
Staff
